Saturday, February 22, 2020

Listening Response Beatles Essay Example | Topics and Well Written Essays - 500 words

Listening Response Beatles - Essay Example In short, the song is appropriately recognized as one of the most complex recordings by the Beatles and the extensive overdubbing and editing has not weakened the effect. On the contrary, as Brennan remarks, it has created "the right setting for a very good song." (Brennan) The overall magical effect of the song is intensified by the sound pattern and the most appreciable feature of the song is the creation of a kind of 'sound picture' in the composition which reflects the feelings of the composer. The other chief characteristics of the song includes its orchestral music, the unusual instruments in lieu of the traditional vocal and musical styles, and sound effects such as cymbals recorded and played backward. According to Roberts, "Strawberry Fields Forever," written by Lennon, evokes the feeling of the flower shows in the Salvation Army Camp, conducted every summer. "His words and music are like a lighthearted walk through a summer garden." (Roberts, 67) Unlike any other rock 'n' roll song of the past, "Strawberry Fields Forever" exploited the recording technology as well as creativity to the maximum. To speak specifically about the composition of the song "Strawberry Fields Forever," it is important to note that Lennon was particular about the lyrics to be like a conversation.

Wednesday, February 5, 2020

Comparison therapy of Tocilizumab+ MTX vs Riruximab+MTX in treatment Essay

Comparison therapy of Tocilizumab+ MTX vs Riruximab+MTX in treatment of active rhuematoid arthritis - Essay Example rature on two new agents, tocilizumab and rituximab was collected, and the reports examining the safety and efficacy of these two novel agents alone or in combination with methotrexate in the treatment of active rheumatoid arthritis were reviewed through a qualitative methodology. Some trials have indicated positive effects of combination of tocilizumab and rituximab with methotrexate. Rituximab successfully causes depletion of B lymphocytes in refractory cases of RA and may be a key component in the interruption of the disease pathogenesis. It is expected that once data from clinical trials are available, tocilizumab will be used with the same goal of increasing symptom-free period and preventing joint destruction. However, based on the results of the literature review, it can be stated that for a long-term therapy of active rheumatoid arthritis, rituximab and methotrexate combination is safer and more efficacious than tocilizumab and methotrexate combination, although more long-term trials are necessary for the later combination. As far as the facts from literature review are concerned, although the efficacy of both these regimens have been established based on standard criteria, and given this scenario, although rough comparison in different parameters of efficacy and safety can be made, a decisive conclusion is not possible without further trial or research. Since there are different parameters of a clinically effective treatment, an identical comparison of both the regimens are needed, with the problem being selection of patients with identical baseline. A comparison is also necessary based on patient’s perception on the symptoms. A future trial involving these criteria may be needed to arrive at a guideline based on these regimens. Figure 6: Percentage of responders according to the American College of Rheumatology (ACR) improvement criteria and the Disease Activity Score in 28 joints (DAS28) as well as mean change in Modified Health Assessment